BIBB 515

CAT: 0931-T4039-02Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0931-T4039-02Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

156635-05-1

Target

Others, LDLR

Related Pathways

Others, Metabolism

Purity

0.9968

Bioactivity

BIBB 515 is a selective and potent inhibitor of OSC in vivo with an ED50 value of 0.2-0.5 and 0.36-33.3 mg/kg in rats and mice, respectively. 2, 3-Oxidosqualene cyclase (OSC) is an important enzyme in the biosynthesis of animal, plant, and fungal sterols. OSC catalyzes the conversion of (3S) -2, 3-oxidosqualene to lanosterol, a precursor to cholesterol, in mammals and fungi. Total cholesterol was reduced by 19% in normolipemic hamsters at a dose of 55 mg/kg/day for 11 days and 25% in hyperlipemic hamsters at a dose of 148 mg/kg/day for 25 days.

Smiles

Clc1ccc(cc1)C(=O)N1CCC(CC1)=Cc1ccc(cc1)C1=NCCO1

Molecular Formula

C22H21ClN2O2

Molecular Weight

380.87

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Chemical Information

Bibb-515

inhibits 2,3-oxidosqualene cyclase; structure in first source

CAS Number	156635-05-1
PubChem CID	501398
IUPAC Name	(4-chlorophenyl)-[4-[[4-(4,5-dihydro-1,3-oxazol-2-yl)phenyl]methylidene]piperidin-1-yl]methanone
Molecular Formula	C22H21ClN2O2
Molecular Weight	380.9
XLogP	3.8
Topological Polar Surface Area	41.9
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	3
Heavy Atom Count	27
Formal Charge	0
Complexity	577

SMILES

C1CN(CCC1=CC2=CC=C(C=C2)C3=NCCO3)C(=O)C4=CC=C(C=C4)Cl

InChI

InChI=1S/C22H21ClN2O2/c23-20-7-5-19(6-8-20)22(26)25-12-9-17(10-13-25)15-16-1-3-18(4-2-16)21-24-11-14-27-21/h1-8,15H,9-14H2

InChIKey

JQNWPWUJMRAASQ-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 156635-05-1

CID: 501398

Formula: C22H21ClN2O2

MW: 380.9

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	380.9
XLogP3	3.8
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	3
Exact Mass	380.1291556
Monoisotopic Mass	380.1291556
Topological Polar Surface Area	41.9 Å²
Heavy Atom Count	27
Formal Charge	0
Complexity	577
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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T81820-01	Meso-Benzothiazole-BODIPY 505/515
T78449-01	8-Phenyl-BODIPY 505/515
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T212563-01	C4 BODIPY 505/515 MG
T85871-01	BODIPY 505/515-8-C3-COOH

Alternative Products

Catalog	Name
584201	BIBB 515
BML-EI340-0050	BIBB-515

BIBB 515

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