BIBB 515

• Target :

  Others|||LDLR

• Related Pathways :

  Others|||Metabolism

• Purity :

  0.9968

• Bioactivity :

  BIBB 515 is a selective and potent inhibitor of OSC in vivo with an ED50 value of 0.2-0.5 and 0.36-33.3 mg/kg in rats and mice, respectively. 2, 3-Oxidosqualene cyclase (OSC) is an important enzyme in the biosynthesis of animal, plant, and fungal sterols. OSC catalyzes the conversion of (3S) -2, 3-oxidosqualene to lanosterol, a precursor to cholesterol, in mammals and fungi. Total cholesterol was reduced by 19% in normolipemic hamsters at a dose of 55 mg/kg/day for 11 days and 25% in hyperlipemic hamsters at a dose of 148 mg/kg/day for 25 days.

• Smiles :

  Clc1ccc(cc1)C(=O)N1CCC(CC1)=Cc1ccc(cc1)C1=NCCO1

• Molecular Formula :

  C22H21ClN2O2

• Molecular Weight :

  380.87

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  156635-05-1