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MRTX849 ethoxypropanoic acid

CAT: 0931-T40190Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T40190Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2561529-98-2
Target
Target Protein Ligand-Linker Conjugate, Others, Kras, Ras
Related Pathways
MAPK, PROTAC, GPCR/G Protein, Others
Bioactivity
MRTX849 ethoxypropanoic acid is a compound that contains a ligand for KRAS G12C and a PROTAC linker. It is commonly employed in the synthesis of PROTAC LC-2, which is a highly effective and innovative PROTAC. LC-2 has been proven to degrade endogenous KRAS G12C with remarkable potency, exhibiting DC50 values ranging from 0.25 to 0.76 μM.
Smiles
OC(=O)CCOCCCN1CCC[C@H]1COc1nc2CN(CCc2c(n1)N1CCN([C@@H](CC#N)C1)C(=O)C(F)=C)c1cccc2cccc(Cl)c12
Molecular Formula
C37H43ClFN7O5
Molecular Weight
720.24
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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