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MRTX849 acid

CAT: 0931-T40189Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T40189Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2561529-96-0
Target
Others, Kras, Ras
Related Pathways
MAPK, Others, GPCR/G Protein
Bioactivity
MRTX849 acid, a derivative of MRTX849, is employed in the synthesis of PROTAC LC-2. LC-2, a potent and pioneering PROTAC, exhibits the ability to efficiently degrade endogenous KRAS G12C with DC50 values ranging between 0.25 and 0.76 μM.
Smiles
OC(=O)CCN1CCC[C@H]1COc1nc2CN(CCc2c(n1)N1CCN([C@@H](CC#N)C1)C(=O)C(F)=C)c1cccc2cccc(Cl)c12
Molecular Formula
C34H37ClFN7O4
Molecular Weight
662.16
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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