RegisterLogin

BMS-986251

CAT: 0931-T40123Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-T40123Size:25 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
CAS Number
2460133-35-9
Target
Others|||Interleukin|||ROR
Related Pathways
Metabolism|||Immunology/Inflammation|||Others
Bioactivity
BMS-986251 is a potent and specific ROR?t inverse agonist that exerts its action via oral administration. It shows an EC 50 of 12 nM for ROR?t GAL4. In human whole blood assay, BMS-986251 effectively inhibits IL-17 with an EC 50 of 24 nM. Furthermore, BMS-986251 exhibits strong therapeutic effects in mouse acanthosis and Imiquimod-induced models, which are commonly used preclinical models for psoriasis.
Smiles
[H][C@@]12CCc3cc(ccc3[C@@]1(CCN2C(=O)[C@@H]1CC[C@H](C[C@@H]1C)C(O)=O)S(=O)(=O)c1ccc(F)cc1)C(F)(C(F)(F)F)C(F)(F)F
Molecular Formula
C30H29F8NO5S
Molecular Weight
667.61
Shipping Conditions
Cool pack
Storage Temperature
-20°C

Related Products

CatalogName
T9164-01BMS-986242
T206353-01BMS-986458
T9901A-878-01BMS-986156
T70214-01BMS-986202
T39448-01BMS-986224
T39647-01BMS-986278
T206575-01BMS-986238
T14685-01BMS-986158
T63966-01BMS-986141
T39789-01BMS-986235

Alternative Products

CatalogName
MBS5800422BMS-986251
MBS386661-01BMS-806 (BMS 378806)
A11201-1BMS-806 (BMS 378806) 1mg
A11201-2BMS-806 (BMS 378806) 2mg
A11201-500BMS-806 (BMS 378806) 500mg
A11201-25BMS-806 (BMS 378806) 25mg
MBS3616196-01BMS 193885
MBS3607783-01BMS-833923
MBS3607487-01BMS-378806
MBS3602996-01BMS-986195

Popular Products