BMS-986251

• Target :

  Others|||Interleukin|||ROR

• Related Pathways :

  Metabolism|||Immunology/Inflammation|||Others

• Bioactivity :

  BMS-986251 is a potent and specific ROR?t inverse agonist that exerts its action via oral administration. It shows an EC 50 of 12 nM for ROR?t GAL4. In human whole blood assay, BMS-986251 effectively inhibits IL-17 with an EC 50 of 24 nM. Furthermore, BMS-986251 exhibits strong therapeutic effects in mouse acanthosis and Imiquimod-induced models, which are commonly used preclinical models for psoriasis.

• Smiles :

  [H][C@@]12CCc3cc(ccc3[C@@]1(CCN2C(=O)[C@@H]1CC[C@H](C[C@@H]1C)C(O)=O)S(=O)(=O)c1ccc(F)cc1)C(F)(C(F)(F)F)C(F)(F)F

• Molecular Formula :

  C30H29F8NO5S

• Molecular Weight :

  667.61

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  2460133-35-9