RET-IN-4

CAT: 0931-T40097Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0931-T40097Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

2436473-55-9

Target

Others, c-RET

Related Pathways

Apoptosis, Tyrosine Kinase/Adaptors, Others

Bioactivity

RET-IN-4 is a highly effective and specific RET inhibitor that can be administered orally. It demonstrates remarkable potency, with IC50 values of 1.29 nM, 1.97 nM, and 0.99 nM for inhibiting RET variants including RET (WT), RET (V804M), and RET (M918T), respectively. Moreover, RET-IN-4 exhibits superior selectivity towards kinases JAK2 (IC50 of 4.4 nM) and FLT3 (IC50 of 30.8 nM) . Additionally, RET-IN-4 possesses pronounced anticancer properties.

Smiles

C[C@H](N1CCOC2(CCN(CC2)c2nc(C)cc(Nc3cc(C)[nH]n3)n2)C1=O)c1ccc(nc1)-n1cc(F)cn1

Molecular Formula

C27H31FN10O2

Molecular Weight

546.611

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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MBS5800404	RET-IN-4
HY-170856	RET ligand-4
R1701-17	RET protein (RET)
V8277-100UG	RET Antibody / c-RET
V8276-100UG	C-RET Antibody / RET
030598	RET (ret proto-oncogene)

RET-IN-4

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