CBR-470-1

• Target :

  PGK1|||Nrf2

• Related Pathways :

  Immunology/Inflammation|||Metabolism

• Purity :

  0.9887

• Bioactivity :

  CBR-470-1 is a potent inhibitor of glycolytic phosphoglycerate kinase 1 (PGK1) that activates NRF2 by increasing methylglyoxal levels. CBR-470-1 is a non-covalent Nrf2 activator with neuroprotective activity that protects SH-SY5Y neuronal cells from MPP+-induced cytotoxicity by activating the Keap1-Nrf2 cascade. cytotoxicity induced by MPP+.

• Smiles :

  S(=O)(=O)([C@@H]1[C@@H](NCC(C)C)CS(=O)(=O)C1)C2=CC=C(Cl)C=C2

• Molecular Formula :

  C14H20ClNO4S2

• Molecular Weight :

  365.9

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  2416095-06-0