CBR-470-1

• Target:

  PGK1|||Nrf2

• Related Pathways:

  Immunology/Inflammation|||Metabolism

• Purity:

  0.9887

• Bioactivity:

  CBR-470-1 is a potent inhibitor of glycolytic phosphoglycerate kinase 1 (PGK1) that activates NRF2 by increasing methylglyoxal levels. CBR-470-1 is a non-covalent Nrf2 activator with neuroprotective activity that protects SH-SY5Y neuronal cells from MPP+-induced cytotoxicity by activating the Keap1-Nrf2 cascade. cytotoxicity induced by MPP+.

• Smiles:

  S (=O) (=O) ([C@@H]1[C@@H] (NCC (C) C) CS (=O) (=O) C1) C2=CC=C (Cl) C=C2

• Molecular Formula:

  C14H20ClNO4S2

• Molecular Weight:

  365.9

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2416095-06-0