CBR-5884

• Target:

  Dehydrogenase

• Related Pathways:

  Metabolism

• Purity:

  >99.99%

• Bioactivity:

  CBR-5884 is an selective, active of phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 33 ?M. CBR-5884 inhibits de novo serine synthesis in cancer cells and is selectively toxic to cancer cell lines with high serine biosynthetic activity. CBR-5884 selectively inhibits the proliferation of melanoma and breast cancer lines that have a high propensity for serine synthesis. Biochemical characterization of the inhibitor revealed that it was a noncompetitive inhibitor that showed a time-dependent onset of inhibition and disrupted the oligomerization state of PHGDH

• Smiles:

  CCOC(=O)c1sc(NC(=O)c2ccco2)c(SC#N)c1C

• Molecular Formula:

  C14H12N2O4S2

• Molecular Weight:

  336.39

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  681159-27-3