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CBR-5884

CAT: 0931-T14884-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0931-T14884-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
681159-27-3
Target
Dehydrogenase
Related Pathways
Metabolism
Purity
>99.99%
Bioactivity
CBR-5884 is an selective, active of phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 33 ?M. CBR-5884 inhibits de novo serine synthesis in cancer cells and is selectively toxic to cancer cell lines with high serine biosynthetic activity. CBR-5884 selectively inhibits the proliferation of melanoma and breast cancer lines that have a high propensity for serine synthesis. Biochemical characterization of the inhibitor revealed that it was a noncompetitive inhibitor that showed a time-dependent onset of inhibition and disrupted the oligomerization state of PHGDH
Smiles
CCOC(=O)c1sc(NC(=O)c2ccco2)c(SC#N)c1C
Molecular Formula
C14H12N2O4S2
Molecular Weight
336.39
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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M22643-01CBR-5884
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