(±) -Equol

CAT: 0931-T4000-01Size: 1 mL - 10 mM (in DMSO)Dry Ice: NoHazardous: No
CAT#:0931-T4000-01Size:1 mL - 10 mM (in DMSO)
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
94105-90-5
Target
Estrogen Receptor/ERR|||Estrogen/progestogen Receptor|||Drug Metabolite
Related Pathways
Metabolism|||Endocrinology/Hormones
Purity
0.9849
Bioactivity
(±) -Equol ((R, S) -Equol) is a non-steroidal estrogen produced from the metabolism of the isoflavonoid phytoestrogen daidzen by human intestinal microflora. The estrogen receptor (ER) agonist activity of the naturally occurring (S) -enantiomer (EC50 = 85 and 65 nM for human ER? and ER?, respectively) is similar to that of genistein but exceeds that of daidzein. (±) -Equol preferentially binds ER? (Ki = 0.73 nM) and demonstrates approximately 9-fold lower affinity for ER? (Ki = 6.41 nM) . (±) -Equol is also a potent antagonist of dihydrotestosterone, which has important implications for prostate cancer and other androgen-mediated pathologies.
Smiles
OC=1C=C2C(CC(CO2)C3=CC=C(O)C=C3)=CC1
Molecular Formula
C15H14O3
Molecular Weight
242.27
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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