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DL-TBOA ammonium

CAT: 0931-T39510Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T39510Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2093503-71-8
Target
Others, transporter
Related Pathways
Metabolism, Others
Bioactivity
DL-TBOA ammonium is a potent, non-transportable inhibitor of excitatory amino acid transporters. Its inhibitory effects are demonstrated by IC50 values of 70 μM, 6 μM, and 6 μM for excitatory amino acid transporter-1 (EAAT1), EAAT2, and EAAT3, respectively. Additionally, DL-TBOA ammonium significantly hampers the uptake of [14C]glutamate in COS-1 cell lines expressing human EAAT1 and EAAT2, evident by Ki values of 42 μM and 5.7 μM, respectively. Furthermore, this compound competitively blocks EAAT4 and EAAT5, with Ki values of 4.4 μM and 3.2 μM, respectively.
Smiles
N.N[C@@H]([C@H](OCc1ccccc1)C(O)=O)C(O)=O
Molecular Formula
C11H16N2O5
Molecular Weight
256.258
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

DL-TBOA ammonium
CAS Number2093503-71-8
PubChem CID91900718
IUPAC Name(2S,3S)-2-amino-3-phenylmethoxybutanedioic acid;azane
Molecular FormulaC11H16N2O5
Molecular Weight256.25
Topological Polar Surface Area111
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count7
Rotatable Bond Count6
Heavy Atom Count18
Formal Charge0
Complexity275
SMILES
C1=CC=C(C=C1)CO[C@@H]([C@@H](C(=O)O)N)C(=O)O.N
InChI
InChI=1S/C11H13NO5.H3N/c12-8(10(13)14)9(11(15)16)17-6-7-4-2-1-3-5-7;/h1-5,8-9H,6,12H2,(H,13,14)(H,15,16);1H3/t8-,9-;/m0./s1
InChIKey
NWSNCKZFVJQJRK-OZZZDHQUSA-N
Chemical Structure
2D Structure
2D structure of DL-TBOA ammonium
CAS: 2093503-71-8
CID: 91900718
Formula: C11H16N2O5
MW: 256.25
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight256.25
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count7
Rotatable Bond Count6
Exact Mass256.10592162
Monoisotopic Mass256.10592162
Topological Polar Surface Area111 Ų
Heavy Atom Count18
Formal Charge0
Complexity275
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
HY-107522BDL-TBOA (ammonium)
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FP13608-01DL-Phosphinothricin ammonium salt
AR-E10083-01DL-Normetanephrine Sulfate Ammonium Salt
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HY-W127365Dimethyl-DL-2,3-distearoyloxypropyl (2-hydroxyethyl) ammonium (acetate)
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B5313-1TFB-TBOA
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