EW-7195

• Target:

  P38 MAPK|||ALK|||TGF-beta/Smad

• Related Pathways:

  MAPK|||Tyrosine Kinase/Adaptors|||Angiogenesis|||Stem Cells

• Purity:

  0.9998

• Bioactivity:

  EW-7195 is a selective and potent inhibitor of ALK5 (TGF?R1) with an IC50 value of 4.83 nM.EW-7195 has an affinity for ALK5 that is more than 300-fold higher than that of p38?.EW-7195 has an inhibitory effect on TGF-?1-induced Smad signaling, epithelial mesenchymal transition (EMT), and breast cancer metastasis to the lungs.

• Smiles:

  Cc1cccc(n1)-c1[nH]c(CNc2cccc(c2)C#N)nc1-c1ccc2ncnn2c1

• Molecular Formula:

  C23H18N8

• Molecular Weight:

  406.44

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1352609-28-9