EW-7195

CAT: 0931-T38752-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0931-T38752-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1352609-28-9
Target
P38 MAPK|||ALK|||TGF-beta/Smad
Related Pathways
MAPK|||Tyrosine Kinase/Adaptors|||Angiogenesis|||Stem Cells
Purity
0.9998
Bioactivity
EW-7195 is a selective and potent inhibitor of ALK5 (TGF?R1) with an IC50 value of 4.83 nM.EW-7195 has an affinity for ALK5 that is more than 300-fold higher than that of p38?.EW-7195 has an inhibitory effect on TGF-?1-induced Smad signaling, epithelial mesenchymal transition (EMT), and breast cancer metastasis to the lungs.
Smiles
Cc1cccc(n1)-c1[nH]c(CNc2cccc(c2)C#N)nc1-c1ccc2ncnn2c1
Molecular Formula
C23H18N8
Molecular Weight
406.44
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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