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JH295

CAT: 0931-T38710Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T38710Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1311143-71-1
Target
Others, MAPK
Related Pathways
MAPK, Others
Bioactivity
JH295 is a highly potent and selective inhibitor of NIMA-related kinase 2 (Nek2), exhibiting irreversible inhibition activity with an IC 50 value of 770 nM. This compound effectively inhibits cellular Nek2 using the alkylation of Cys22. Importantly, JH295 does not exhibit any inhibitory effects toward Cdk1, Aurora B, or Plk1, which are kinases involved in mitotic processes. Furthermore, JH295 has no impact on bipolar spindle assembly or the spindle assembly checkpoint mechanism.
Smiles
CCc1nc(C)c(\C=C2/C(=O)Nc3ccc(NC(=O)C#C)cc23)[nH]1
Molecular Formula
C18H16N4O2
Molecular Weight
320.352
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
LCC14371-01JH295
GTR19187503JH295 hydrate
HY-116423AJH295 (hydrate)

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