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GSK717

CAT: 0931-T38361-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T38361-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1595278-21-9
Target
NOD-like Receptor (NLR), IL Receptor, NOD
Related Pathways
Immunology/Inflammation, NF-κB
Purity
0.9901
Bioactivity
GSK717 is a potent, selective NOD2 (nucleotide-binding oligomerization domain 2) inhibitor that inhibits muramyl dipeptide (MDP) -induced NOD2-mediated signaling with an IC50 of 400 nM for MDP-stimulated IL-8 secretion in HEK293/hNOD2 cells[1]. It blocks the synergy between NOD2 and TLR2 without affecting NOD1, TNFR1, and TLR2-mediated responses. At 5 μM, GSK717 inhibits the release of IL-8, IL-6, TNFα, and IL-1β in primary human monocytes stimulated with MDP[1]. [1]. Rickard DJ, et al. Identification of benzimidazole diamides as selective inhibitors of the nucleotide-binding oligomerization domain 2 (NOD2) signaling pathway. PLoS One. 2013;8 (8) :e69619. Published 2013 Aug 1.
Smiles
CN(CCc1nc2ccccc2n1CC(=O)Nc1ccc2CCCc2c1)C(=O)c1ccccc1
Molecular Formula
C28H28N4O2
Molecular Weight
452.55
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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