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DYn-2

CAT: 0931-T38351-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T38351-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1354630-46-8
Target
Others
Related Pathways
Others
Bioactivity
Mild oxidation can convert the sulfhydryl group of cysteine residues on proteins to cysteine-sulfenic acid derivatives (Cys-SOH) . Protein sulfenylation, then, is a post-translational modification that is relevant to redox signaling. DYn-2 is a chemoselective probe for detecting sulfenylated proteins in intact cells. DYn-2 consists of 1,3-cyclohexanedione coupled to an alkyne moiety by a 3-carbon spacer. The cyclohexanedione group selectively reacts with protein sulfenic acid modifications. The alkyne group of DYn-2 can then be detected using azide-bearing tags by standard click chemistry. This approach offers superior sensitivity relative to using azide-modified probes with alkynyl detection tags.
Smiles
O=C1CCC(CCCC#C)C(=O)C1
Molecular Formula
C11H14O2
Molecular Weight
178.2277
Shipping Conditions
Ice Packs
Storage Temperature
-20°C