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Jaceosidin

CAT: 0931-T3824-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T3824-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
18085-97-7
Target
COX, Apoptosis, Bcl-2 Family, UGT
Related Pathways
Immunology/Inflammation, Apoptosis, Metabolism, Neuroscience
Purity
0.9997
Bioactivity
Jaceosidin has anti-oxidative activity. Jaceosidin has anti-inflammatory activity, also a microglial inhibitor with anti-neuroinflammation activity. aceosidin has anticancer activity, modulates the ERK/ATM/Chk1/2 pathway, leading to inactivation of the Cdc2-cyclin B1 complex, followed by G2/M cell cycle arrest in endometrial cancer cells. Jaceosidin has immunosuppressive effect through inhibiting T cell proliferation and activation, which is closely associated with its potent down-regulation of the IFN-γ/STAT1/T-bet signaling pathway. The pharmacokinetics of Jaceosidin may be dramatically affected by polymorphic CYP1A2, UGT1A1, and UGT1A7 responsible for the metabolism of Jaceosidin or by the coadministration of relevant CYP1A2 or UGT inhibitors or inducers.
Smiles
COc1cc(ccc1O)-c1cc(=O)c2c(O)c(OC)c(O)cc2o1
Molecular Formula
C17H14O7
Molecular Weight
330.29
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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