11-cis Retinal

• Target:

  Others|||Endogenous Metabolite

• Related Pathways:

  Metabolism|||Others

• Bioactivity:

  11-cis Retinal is a chromophore that binds to opsin in the mammalian visual system as an inverse agonist forming the inactive conformation of rhodopsin. When 11-cis retinal absorbs a photon of light, it isomerizes to form all-trans retinal beginning the phototransduction cycle, which is the basis for mammalian vision. A G121L mutation in opsin allows 11-cis retinal to bind as a partial agonist and activate rhodopsin in the absence of light. In a moth model of carotenoid deficiency-induced low visual sensitivity, 11-cis retinal application to compound eyes restored visual sensitivity almost completely.

• Smiles:

  C/C (/C=C\C=C (/C) \C=C\C1=C (C) CCCC1 (C) C) =C\C=O |c:9|

• Molecular Formula:

  C20H28O

• Molecular Weight:

  284.443

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  564-87-4