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11-cis Retinal

CAT: 0931-T38219Size: 2 mgDry Ice: NoHazardous: No
CAT#:0931-T38219Size:2 mg
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CAS Number
564-87-4
Target
Others|||Endogenous Metabolite
Related Pathways
Metabolism|||Others
Bioactivity
11-cis Retinal is a chromophore that binds to opsin in the mammalian visual system as an inverse agonist forming the inactive conformation of rhodopsin. When 11-cis retinal absorbs a photon of light, it isomerizes to form all-trans retinal beginning the phototransduction cycle, which is the basis for mammalian vision. A G121L mutation in opsin allows 11-cis retinal to bind as a partial agonist and activate rhodopsin in the absence of light. In a moth model of carotenoid deficiency-induced low visual sensitivity, 11-cis retinal application to compound eyes restored visual sensitivity almost completely.
Smiles
C/C(/C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C)=C\C=O|c:9|
Molecular Formula
C20H28O
Molecular Weight
284.443
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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