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AL 6598

CAT: 0931-T38113-01Size: 500 µgDry Ice: NoHazardous: No
CAT#:0931-T38113-01Size:500 µg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
170291-06-2
Target
Others|||Prostaglandin Receptor
Related Pathways
Immunology/Inflammation|||Others|||GPCR/G Protein
Bioactivity
Elevated intraocular pressure (IOP) is an important risk factor in developing glaucoma. Certain prostaglandins such as PGF2? and PGD2, have been shown to reduce IOP. AL 6598 is the isopropyl ester prodrug of AL 6556, a PGD2 receptor agonist that binds to DP receptors with a Ki value of 3.2 ?M and demonstrates an EC50 value of 0.80 ?M in an in vitro functional assay. Designed to enhance corneal absorption, AL 6598 produces a maximum 53% drop in IOP of the ocular hypertensive monkey with a 1 ?g dose given twice daily.
Smiles
C(C[C@@H](O)C1CCCCC1)[C@@H]2[C@@H](C/C=C\COCC(OC(C)C)=O)[C@H](Cl)C[C@H]2O
Molecular Formula
C23H39ClO5
Molecular Weight
431.01
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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