AZ 1729

CAT: 0931-T37896Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-T37896Size:10 mg
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2016864-46-1
Target
GPCR|||Others
Related Pathways
Endocrinology/Hormones|||GPCR/G Protein|||Others
Bioactivity
FFA2 allosteric agonist. Inhibits forskolin-induced cAMP increase and stimulates 35SGTP?S binding in biochemical assays (pEC50 values are 6.9 and 7.23, respectively) . Binds at allosteric binding site. In functional assays, displays positive allosteric modulation of FFA-induced Gi signaling and negative allosteric modulation of FFA-induced Gq/G11 signaling. Inhibits lipolytic effect of isoproterenol (pEC50 = 5.03) and induces migration of human neutrophils in vitro.
Smiles
Cc1nc(NC(N)=N)sc1-c1cccc(NC(=O)c2ccc(F)cc2)c1
Molecular Formula
C18H16FN5OS
Molecular Weight
369.42
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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