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Kigamicin C

CAT: 0931-T37844Size: 500 µgDry Ice: NoHazardous: No
CAT#:0931-T37844Size:500 µg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
680571-51-1
Target
Others|||Antibiotic|||Antibacterial
Related Pathways
Others|||Microbiology/Virology
Bioactivity
Kigamicins are natural antitumor antibiotics that selectively kill pancreatic cancer PANC-1 cells only under nutrient-starved conditions. They also show antimicrobial activity against Gram-positive bacteria, including methicillin-resistant S. aureus. Kigamicin C inhibits PANC-1 cell survival in nutrient-deprived media at a 100-fold lower concentration than that required for cells maintained in nutrient-rich media. A related compound, kigamicin D, is active in vivo, suppressing the tumor growth of several pancreatic cancer cell lines in nude mice. It blocks the activation of Akt induced in PANC-1 cells placed in nutrient-deprived media. Kigamicin can also induce necrosis in human myeloma cells, but not normal lymphocytes, maintained in nutrient-rich media (CC50 = 100 nM) .
Smiles
[H][C@]12Cc3cc4C[C@@]5(C)OCCN5C(=O)c4c(O)c3-c3c(O)c4c(oc5[C@@H](O)[C@@H](C[C@H](O)c5c4=O)O[C@H]4CC[C@H](O[C@H]5C[C@@H](OC)[C@H](O)[C@@H](C)O5)[C@@H](C)O4)c(OCO1)c23
Molecular Formula
C41H47NO16
Molecular Weight
809.818
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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