10-Nitrolinoleic acid

CAT: 0931-T37787-01Size: 100 µgDry Ice: NoHazardous: No

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CAT#:0931-T37787-01Size:100 µg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

774603-04-2

Target

Others, PPAR

Related Pathways

Others, Metabolism, DNA Damage/DNA Repair

Bioactivity

10-Nitrolinoleate is the product of nitration of linoleate by NO-derived reactive species. Other nitrolinoleates detected in human plasma and urine include 9-, 12-, and 13-nitrolinoleate. Nitrolinoleates activate peroxisome proliferator-activated receptor γ (PPARγ; Ki = 133 nM), inducing CD36 expression in macrophages, adipocyte differentiation, and glucose uptake. Nitrolinoleates can also be metabolized by smooth muscle cells to produce nitrite derivatives which in turn form NO, leading to increased cGMP production and smooth muscle relaxation. Through the same mechanism, nitrolinoleate-derived NO suppresses leukocyte adhesion, in part through nitrosation of CD40. Alteratively, nitrolinoleates can act independently of NO/cGMP and PPARγ signaling to suppress neutrophil and macrophage functions.

Smiles

C(=C\CCCCCCCC(O)=O)(\C/C=C\CCCCC)/N(=O)=O

Molecular Formula

C18H31NO4

Molecular Weight

325.44

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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Alternative Products

Catalog	Name
HY-113473	10-Nitrolinoleic acid
PC106513	10,10,10-Trifluorodecanoic acid
MBS393763-01	Decanoic-10,10,10-D3 Acid
HY-W108237	10- (Benzyloxy) -10-oxodecanoic acid
OR1059005-01	10-Amino-10-oxodecanoic acid
C6968-100	10-Undecenoic acid
FA40762-01	Arachidonic acid - 10%
FO183674-01	10-Oxooctadecanoic acid
HY-121785	10-Thiofolic acid
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10-Nitrolinoleic acid

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