Polygalacic acid

• Target:

  AChR|||MMP|||Cholinesterase (ChE)

• Related Pathways:

  Neuroscience|||Proteases/Proteasome

• Purity:

  0.9982

• Bioactivity:

  Polygalacic acid (Virgaureagenin G) is a triterpenoid isolated from the root of Polygala tenuifolia Willd that inhibits MMP expression. Polygalacic acid (Virgaureagenin G) can significantly improve the responsiveness of the cholinergic system, such as decreased acetylcholinesterase (AChE) activity, increased choline acetyltransferase (ChAT) activity, and increased acetylcholine (ACh) levels in the hippocampus and frontal cortex. Polygalacic acid (Virgaureagenin G) can also inhibit IL-1?-induced Wnt/?-catenin activation and mitogen-activated protein kinase (MAPK) signaling pathways in chondrocytes, and is used in osteoarthritis (OA) related research.

• Smiles:

  CC1(C)CC[C@@]2([C@H](O)C[C@]3(C)C(=CC[C@@H]4[C@@]5(C)C[C@H](O)[C@H](O)[C@@](C)(CO)[C@@H]5CC[C@@]34C)[C@H]2C1)C(O)=O

• Molecular Formula:

  C30H48O6

• Molecular Weight:

  504.7

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  22338-71-2