BX-320

CAT: 0931-T37561-01Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0931-T37561-01Size:25 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

702676-93-5

Target

Others, PDK

Related Pathways

PI3K/Akt/mTOR signaling, Others

Bioactivity

BX-320 is an inhibitor of the serine/threonine kinase 3-phosphoinositide-dependent protein kinase 1 (PDK1; IC50= 30 nM) .1It is selective for PDK1 over a panel of 10 additional kinases (IC50s = >820 nM for all) . BX-320 inhibits Akt and p70S6K1 phosphorylation in PC3 cells (IC50s = 1-3 μM) . It induces apoptosis in, and inhibits the growth of, MDA-MB-468 breast cancer cells (IC50s = 0.5 and 0.6 μM, respectively), as well as inhibits cell growth in a panel of cancer cells (IC50s = 0.12-1.2 μM) . BX-320 (200 mg/kg) inhibits the growth of lung tumors in a LOX melanoma mouse model of blood-borne metastasis.

Smiles

CC(C)(C(N)=O)C(=O)NCCCNC1=NC(NC2=CC=CC(NC(=O)N3CCCC3)=C2)=NC=C1Br

Molecular Formula

C23H31BrN8O3

Molecular Weight

547.45

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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