BX-320

• Target:

  Others|||PDK

• Related Pathways:

  PI3K/Akt/mTOR signaling|||Others

• Bioactivity:

  BX-320 is an inhibitor of the serine/threonine kinase 3-phosphoinositide-dependent protein kinase 1 (PDK1; IC50= 30 nM) .1It is selective for PDK1 over a panel of 10 additional kinases (IC50s = >820 nM for all) . BX-320 inhibits Akt and p70S6K1 phosphorylation in PC3 cells (IC50s = 1-3 ?M) . It induces apoptosis in, and inhibits the growth of, MDA-MB-468 breast cancer cells (IC50s = 0.5 and 0.6 ?M, respectively), as well as inhibits cell growth in a panel of cancer cells (IC50s = 0.12-1.2 ?M) . BX-320 (200 mg/kg) inhibits the growth of lung tumors in a LOX melanoma mouse model of blood-borne metastasis.

• Smiles:

  CC(C)(C(N)=O)C(=O)NCCCNC1=NC(NC2=CC=CC(NC(=O)N3CCCC3)=C2)=NC=C1Br

• Molecular Formula:

  C23H31BrN8O3

• Molecular Weight:

  547.45

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  702676-93-5