DOPAL

• Target:

  Endogenous Metabolite|||Others|||Reactive Oxygen Species

• Related Pathways:

  Metabolism|||Immunology/Inflammation|||NF-?B|||Others

• Bioactivity:

  DOPAL is an aldehyde product of the oxidative deamination of dopamine by monoamine oxidase.[1] It can be further oxidized to 3,4-dihydroxyphenylacetic acid (DOPAC) by aldehyde dehydrogenase (ALDH) and, to a lesser extent reduced to 3,4-dihydroxyphenyl ethanol (DOPET) . DOPAL is toxic to neurons.[2], [3] It can also oligomerize and precipitate ?-synuclein, an event associated with Parkinson's disease.[2] Mice lacking cytosolic and mitochondrial forms of ALDH display increased levels of DOPAL as well as neurodegeneration and motor dysfunction characteristic of Parkinson's disease.[4]

• Smiles:

  O=CCC1=CC=C (O) C (O) =C1

• Molecular Formula:

  C8H8O3

• Molecular Weight:

  152.15

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  5707-55-1