NS 383

• Target:

  Sodium Channel|||Others

• Related Pathways:

  Membrane transporter/Ion channel|||Others

• Bioactivity:

  ASIC blocker (IC50 values are 0.44, 2.1 ?M and no effect at rat ASIC1a, ASIC3 and ASIC2a, respectively: IC50 value = 0.12 ?M at human ASIC1a with no effect at ASIC2a or ASIC3) . Inhibition was also observed at heteromeric ASIC channels (IC50 values are 0.79, 0.87 and 4.5 uM at rat ASIC1a+3, ASIC1a+2a and ASIC2a+3; IC5O values are 0.33 and 0.69 uM at human ASIC1a+2a and ASIC1a+3, with no effect at ASIC2a+3) . Attenuates pathophysiological nociceptive behaviors in CFA-inflamed and CCI rats.

• Smiles:

  N(O)=C1C2=C(C3=C(C(=C2)C4=CC=CC=C4)CCN(CC)C3)NC1=O

• Molecular Formula:

  C19H19N3O2

• Molecular Weight:

  321.37

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  309711-59-9