NS 383

CAT: 0931-MF-0006600Size: 2 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0006600Size:2 mg
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CAS Number
309711-59-9
Target
Sodium Channel|||Others
Related Pathways
Membrane transporter/Ion channel|||Others
Bioactivity
ASIC blocker (IC50 values are 0.44, 2.1 ?M and no effect at rat ASIC1a, ASIC3 and ASIC2a, respectively: IC50 value = 0.12 ?M at human ASIC1a with no effect at ASIC2a or ASIC3) . Inhibition was also observed at heteromeric ASIC channels (IC50 values are 0.79, 0.87 and 4.5 uM at rat ASIC1a+3, ASIC1a+2a and ASIC2a+3; IC5O values are 0.33 and 0.69 uM at human ASIC1a+2a and ASIC1a+3, with no effect at ASIC2a+3) . Attenuates pathophysiological nociceptive behaviors in CFA-inflamed and CCI rats.
Smiles
N(O)=C1C2=C(C3=C(C(=C2)C4=CC=CC=C4)CCN(CC)C3)NC1=O
Molecular Formula
C19H19N3O2
Molecular Weight
321.37
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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