M62812

• Target :

  TLR

• Related Pathways :

  Immunology/Inflammation

• Purity :

  0.9907

• Bioactivity :

  TLR4 inhibitor. Inhibits LPS-induced NF-?B activation in HEK293 cells (IC50 = 2.4 ?g/mL) . Also inhibits LPS-induced cytokine production and procoagulant effects in PBMCs and HUVECs. Prolongs survival in a mouse septic shock model.

• Smiles :

  Cl.Cl.NC1=NSC2=C1C=CC(OC1=C(N)C=CC=C1)=C2

• Molecular Formula :

  C13H13Cl2N3OS

• Molecular Weight :

  330.23

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  613263-00-6