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14,15-Leukotriene E4

CAT: 0931-T37262-01Size: 25 µgDry Ice: NoHazardous: No
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CAT#:0931-T37262-01Size:25 µg
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CAS Number
1000852-57-2
Target
Drug Metabolite, Others
Related Pathways
Metabolism, Others
Bioactivity
Leukotrienes (LTs) are a group of acute inflammatory mediators derived from arachidonic acid in leukocytes. The majority of these metabolites are formed through the 5-lipoxygenase (5-LO) pathway. 14,15-LTE4 is a metabolite of 14,15-LTC4 and 14,15-LTD4, an alternate class of LTs synthesized by a pathway involving the dual actions of 15- and 12-LOs on arachidonic acid via 15-HpETE and 14,15-LTA4 intermediates. These metabolites are classified as eoxins because they are formed mostly by eosinophils. Mast cells and nasal polyps can synthesize 14,15-LTC4 as well, however metabolism to 14,15-LTE4 in these cells and tissue has not been documented. 14,15-LTE4 increases vascular permeability of human endothelial cell monolayers with about 10-fold less potency than LTC4, but approximately 100-fold greater potency than histamine.
Smiles
CCCCC[C@H](O)[C@H](SC[C@H](N)C(O)=O)\C=C\C=C\C=C/C\C=C/CCCC(O)=O
Molecular Formula
C23H37NO5S
Molecular Weight
439.61
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

1000852-57-2

PubChem
cas1000852-57-2
modify2026-05-17
descriptionEoxin E4 is a leukotriene that is the 14R-(S-cysteinyl),15S-hydroxy derivative of (5Z,8Z,10E,12E)-icosa-7,9,11,14-tetraenoic acid. It has a role as a metabolite. It is an eoxin and a leukotriene. It is functionally related to a (5Z,8Z,10E,12E)-icosatetraenoic acid.
synonyms
14,15-Leukotriene E4eoxin E4EXE414,15-LTE4CHEBI:63986
15S-hydroxy,14R-(S-cysteinyl)-5Z,8Z,10E,12E-eicosatetraenoic acid
DTXSID601032109RefChem:78565DTXCID7015171121000852-57-2+ 15 more
PubChem LinkClick here

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MBS579820514,15-Leukotriene E4
ADA2906414,15-Leukotriene d4
sc-20501214,15-Leukotriene C4
MBS578516614,15-dehydro Leukotriene B4
sc-220608A14,15-Leukotriene A4 Methyl Ester
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