HS271

CAT: 0931-T37082-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0931-T37082-01Size:1 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

2410393-15-4

Target

IRAK

Related Pathways

NF-κB, Immunology/Inflammation

Purity

0.9879

Bioactivity

HS271 is a selective, highly potent and orally active IRAK4 inhibitor (IC50= 7.2 μM) . HS271 shows excellent enzymatic and cellular activities, as well as excellent pharmacokinetic properties.

Smiles

CN(C)CCn1cc2cc(NC(=O)c3cccc(n3)C(F)(F)F)c(cc2n1)C(C)(C)O

Molecular Formula

C21H24F3N5O2

Molecular Weight

435.44

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Chemical Information

CID 146386401

CAS Number	2410393-15-4
PubChem CID	146386401
IUPAC Name	N-[2-[2-(dimethylamino)ethyl]-6-(2-hydroxypropan-2-yl)indazol-5-yl]-6-(trifluoromethyl)pyridine-2-carboxamide
Molecular Formula	C21H24F3N5O2
Molecular Weight	435.4
XLogP	2.8
Topological Polar Surface Area	83.3
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	6
Heavy Atom Count	31
Formal Charge	0
Complexity	631

SMILES

CC(C)(C1=CC2=NN(C=C2C=C1NC(=O)C3=NC(=CC=C3)C(F)(F)F)CCN(C)C)O

InChI

InChI=1S/C21H24F3N5O2/c1-20(2,31)14-11-16-13(12-29(27-16)9-8-28(3)4)10-17(14)26-19(30)15-6-5-7-18(25-15)21(22,23)24/h5-7,10-12,31H,8-9H2,1-4H3,(H,26,30)

InChIKey

QAOWCAZEVIIQTF-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 2410393-15-4

CID: 146386401

Formula: C21H24F3N5O2

MW: 435.4

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	435.4
XLogP3	2.8
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	6
Exact Mass	435.18820951
Monoisotopic Mass	435.18820951
Topological Polar Surface Area	83.3 Å²
Heavy Atom Count	31
Formal Charge	0
Complexity	631
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
HY-131903-01	HS271

HS271

Chemical Information

Alternative Products

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