Products for Research Use Only
RegisterLogin

PKUMDL-LC-101-D04

CAT: 0931-T36935-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0931-T36935-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
CAS Number
2143896-83-5
Target
GPX, Glutathione Peroxidase
Related Pathways
Oxidation-Reduction, Metabolism
Purity
0.9965
Bioactivity
PKUMDL-LC-101-D04 is a potent allosteric activator of glutathione peroxidase 4 (GPX4), a regulator of ferroptosis. GPX4 activity was increased to 150% of control levels when used at a concentration of 20 μM in a cell-free assay, and at a concentration of 61 μM in wild-type, but not Gpx4-/-, mouse embryonic fibroblast (MEF) extracts.PKUMDL-LC-101-D04 (200 μM) reduced cholesterol peroxide-induced MEF death.
Smiles
Cl.NCCNS(=O)(=O)c1ccc(NC(=S)NC2CCCC2)cc1
Molecular Formula
C14H23ClN4O2S2
Molecular Weight
378.94
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

Pkumdl-LC-101-D04
CAS Number2143896-83-5
PubChem CID155543553
IUPAC Name1-[4-(2-aminoethylsulfamoyl)phenyl]-3-cyclopentylthiourea;hydrochloride
Molecular FormulaC14H23ClN4O2S2
Molecular Weight378.9
Topological Polar Surface Area137
Hydrogen Bond Donor Count5
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Heavy Atom Count23
Formal Charge0
Complexity450
SMILES
C1CCC(C1)NC(=S)NC2=CC=C(C=C2)S(=O)(=O)NCCN.Cl
InChI
InChI=1S/C14H22N4O2S2.ClH/c15-9-10-16-22(19,20)13-7-5-12(6-8-13)18-14(21)17-11-3-1-2-4-11;/h5-8,11,16H,1-4,9-10,15H2,(H2,17,18,21);1H
InChIKey
FELDRJSFLBINQS-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Pkumdl-LC-101-D04
CAS: 2143896-83-5
CID: 155543553
Formula: C14H23ClN4O2S2
MW: 378.9
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight378.9
Hydrogen Bond Donor Count5
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Exact Mass378.0950960
Monoisotopic Mass378.0950960
Topological Polar Surface Area137 Ų
Heavy Atom Count23
Formal Charge0
Complexity450
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

Related Products

CatalogName
T28424-01PKUMDL-WQ-2101
T28425PKUMDL-WQ-2201
T28423-01PKUMDL-LTQ-301
T41026-01Biotin-LC-LC-NHS
T87478-01Sulfo-NHS-LC-LC-Biotin
T25648-01LC 6
T36256-01LC-2
T69679-01LC-1028
T210990-01LC-PDin06
T69681-01LC-1310

Alternative Products

CatalogName
BA3442-5PKUMDL-LC-101-D04
BA8245-50PKUMDL-WQ-2201
BA8243-10PKUMDL-WQ-2101
SYA47491-01PKUMDL WQ 2201

Popular Products