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(Rac) -SAR131675

CAT: 0931-T3691-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T3691-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1092539-44-0
Target
VEGFR
Related Pathways
Angiogenesis, Tyrosine Kinase/Adaptors
Purity
0.991
Bioactivity
(Rac) -SAR131675 is an effective and specific VEGFR-3 inhibitor. It inhibited VEGFR-3 tyrosine kinase activity (IC50: 20 nmol/L) and VEGFR-3 autophosphorylation (IC50: 45 nmol/L) in HEK cells, respectively. SAR131675 is highly specific for VEGFR-3 versus 107 receptors, enzymes, ion channels, and 65 kinases. SAR131675 is a highly specific VEGFR-3-TK inhibitor with significant antitumoral and antimetastatic activities in vivo through inhibition of lymphangiogenesis and TAM invasion.
Smiles
CCn1c(N)c(C(=O)NC)c(=O)c2ccc(nc12)C#C[C@@](C)(O)COC
Molecular Formula
C18H22N4O4
Molecular Weight
358.39
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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