Isogarcinol

• Target :

  Others|||Cholinesterase (ChE) |||Parasite

• Related Pathways :

  Neuroscience|||Microbiology/Virology|||Others

• Bioactivity :

  Isogarcinol is a natural polyisoprenylated benzophenone first isolated from plant species in the genus Garcinia. It has immunosuppressant actions, inhibiting the protein phosphatase calcineurin (IC50 = 36 ?M) and suppressing the proliferation of T cells. Oral administration of isogarcinol in mice decreases delayed type hypersensitivity, prolongs graft survival in allogeneic skin transplants, suppresses inflammation in collagen-induced arthritis, and reduces clinical symptoms in experimental autoimmune encephalomyelitis. Isogarcinol inhibits the proliferation of HL-60 and PC-3 cancer cells (IC50s = 4 and 8 ?g/ml, respectively) through cell cycle arrest and apoptosis.

• Smiles :

  CC(C)=CC[C@H]1C[C@@]23C[C@@H](CC=C(C)C)C(C)(C)[C@@](CC=C(C)C)(C(=O)C(C(=O)c4ccc(O)c(O)c4)=C2OC1(C)C)C3=O

• Molecular Formula :

  C38H50O6

• Molecular Weight :

  602.8

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  71117-97-0