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Bisubstrate Inhibitor 78

CAT: 0931-T36802Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T36802Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2368247-39-4
Target
Others
Related Pathways
Others
Bioactivity
Bisubstrate inhibitor 78 is an inhibitor of nicotinamide N-methyltransferase (NNMT; IC50= 1.41 μM) .1It binds the NNMT active site in the binding pockets for the NNMT substrates S-adenosyl-L-methionine (SAM) and nicotinamide . Bisubstrate inhibitor 78 is selective for NNMT over histone-lysine N-methytransferase NSD2 and protein arginine methyltransferase 1 (PRMT1; IC50s = >50 μM for both) . It reduces levels of 1-methylnicotinamide in, and inhibits proliferation of, HSC-2 oral cancer cells when used at a concentration of 100 μM.This compound is unstable in powder form and other related salt forms are recommended.
Smiles
O[C@H]1[C@H](N2C=3C(N=C2)=C(N)N=CN3)O[C@H](CN(CC4=CC5=C(C=C4)C=CC=C5)CC[C@@H](C(O)=O)N)[C@H]1O
Molecular Formula
C25H29N7O5
Molecular Weight
507.54
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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