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Binucleine 2

CAT: 0931-T36801-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T36801-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
220088-42-6
Target
Others, Aurora Kinase
Related Pathways
Cell Cycle/Checkpoint, Others, Chromatin/Epigenetic
Bioactivity
Binucleine 2 is an isoform-specific and ATP-competitive inhibitor of Drosophila Aurora B kinase (Ki = 0.36 μM), specifically inhibiting it in a dose-dependent manner while exhibiting minimal inhibition of human or X. laevis Aurora B kinases at concentrations up to 100 μM. At 40 μM, Binucleine 2 induces mitotic and cytokinesis defects in Drosophila Kc167 cells and prevents the assembly of a contractile ring during cell division in Drosophila S2 cells, but it does not affect ring ingression, indicating that Aurora B kinase activity is not required for that process.
Smiles
N(=CN(C)C)C=1N(N=CC1C#N)C2=CC(Cl)=C(F)C=C2
Molecular Formula
C13H11ClFN5
Molecular Weight
291.71
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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CatalogName
MBS5797853Binucleine 2

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