CDPCP

CAT: 0931-T36745Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0931-T36745Size:1 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

106343-59-3

Target

Others

Related Pathways

Others

Bioactivity

CDPCP is a platinum-containing DNA-crosslinking agent.1Unlike cisplatin or oxaliplatin , cDPCP forms monofunctional DNA adducts. It is transported into cells by organic cation transporter 1 (OCT1) and OCT2, inhibiting proliferation of MDCK cells expressing the human transporters with IC50values of 8.1 and 1.5 μM, respectively. cDPCP inhibits RNA polymerase II-mediated transcription in a reporter assay using HeLa cells. It increases survival in murine S180 sarcoma and P388 leukemia models when administered at doses of 40 and 80 mg/kg, respectively.2

Smiles

[Cl-].[NH][Pt++]([NH])([Cl-])[N]1=CC=CC=C1 |c:6,8,t:4,^1:1,3,4,5|

Molecular Formula

C5H7Cl2N3Pt

Molecular Weight

375.12

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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Catalog	Name
HY-W781133-01	CDPCP

CDPCP

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