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Caylin-2

CAT: 0931-T36465-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T36465-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1392830-09-9
Target
MDM-2/p53, Others
Related Pathways
Apoptosis, Others
Bioactivity
Nutlin-3 is an activator of p53 that functions by inhibiting the interaction of p53 with MDM2, a negative regulator of p53 activity. Caylin-2 is a nutlin-3 analog in which trifluoromethyl groups have been substituted for chlorine on the 2 phenyl rings. At high concentrations, caylin-2 inhibits the growth of HCT116 cells with an IC50 of approximately 8 μM, making it about 10-fold less potent than nutlin-3. Interestingly, at concentrations between 5-100 nM, caylin-2 promotes the growth of HCT116 cells approximately 40% compared to untreated cells. The mechanism of the growth promoting properties of caylin-2 have not yet been elucidated.
Smiles
C(=O)(N1[C@H]([C@H](N=C1C2=C(OC(C)C)C=C(OC)C=C2)C3=CC=C(C(F)(F)F)C=C3)C4=CC=C(C(F)(F)F)C=C4)N5CC(=O)NCC5
Molecular Formula
C32H30F6N4O4
Molecular Weight
648.6
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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