RSL3

• Target:

  Glutathione Peroxidase|||ROS|||GPX|||Reactive Oxygen Species|||p62|||Ferroptosis

• Related Pathways:

  Immunology/Inflammation|||Oxidation-Reduction|||Apoptosis|||Metabolism|||Autophagy|||NF-?B

• Purity:

  0.9996

• Bioactivity:

  RSL3 (RSL3 1S) is an inhibitor of GPX4, and inhibits system xc- that blocks GSH synthesis (IC50=100 nM) . RSL3 is a VDAC-independent activator of ferroptosis that is selective for tumor cells carrying oncogenic RAS.

• Smiles:

  COC (=O) [C@H]1Cc2c ([nH]c3ccccc23) [C@@H] (N1C (=O) CCl) c1ccc (cc1) C (=O) OC

• Molecular Formula:

  C23H21ClN2O5

• Molecular Weight:

  440.88

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1219810-16-8