TAN 420E

• Target:

  Others|||ROS|||Antibiotic

• Related Pathways:

  Others|||Immunology/Inflammation|||Microbiology/Virology

• Bioactivity:

  TAN 420E is a bacterial metabolite originally isolated from Streptomyces. It scavenges 2,2-diphenyl-1-picrylhydrazyl radicals in a cell-free assay (IC50 = 1.3 ?M) and reduces thiobarbituric acid reactive substances (TBARS) in rat liver microsomes by 72% when used at a concentration of 100 ?g/ml. TAN 420E is active against B. brevis, B. cereus, M. flavus, and S. aureus (MICs = 50-100 ?g/ml) . It is cytotoxic to P388 and KB lymphocytic leukemia cells (EC50s = 0.022 and 0.3 ?g/ml, respectively) .

• Smiles:

  CO[C@H]1C[C@H](C)[C@@H](OC)c2cc(O)cc(NC(=O)\C(C)=C/C=C/[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1OC)c2O|c:19,t:21,32|

• Molecular Formula:

  C30H44N2O9

• Molecular Weight:

  576.687

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  91700-93-5