SB-612111

CAT: 0931-T36376-01Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0931-T36376-01Size:25 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

371980-98-2

Target

Opioid Receptor, Others

Related Pathways

Neuroscience, Endocrinology/Hormones, GPCR/G Protein, Others

Bioactivity

SB-612111 is a novel and potent human opiate receptor-like orphan receptor (ORL-1) antagonist with a high affinity for hORL-1 (Ki = 0.33 nM) . It exhibits selectivity for μ-, κ-, and δ-receptors with Ki values of 57.6 nM, 160.5 nM, and 2109 nM, respectively. SB-612111 effectively antagonizes the pronociceptive action of Nociceptin in an acute pain model[1].

Smiles

ClC1=C(C2CCN(C[C@@H]3C[C@H](O)C=4C(CC3)=C(C)C=CC4)CC2)C(Cl)=CC=C1

Molecular Formula

C24H29Cl2NO

Molecular Weight

418.4

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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Alternative Products

Catalog	Name
GTR19191465-01	SB-612111
B7433-10	SB 612111 hydrochloride
MBS3604284-01	SB-612111 hydrochloride
HY-18618A-01	SB-612111 (hydrochloride)
GTR19200856-01	Rel-SB-612111 hydrochloride
HY-18617	Rel-SB-612111 (hydrochloride)
GTR19153626-01	SB-269970, SB 269970
217783	SB-277011-A Dihydrochloride (SB277011A, SB 277011A, Dopamine D3 Receptor Antagonist, SB-277011-A, SB-277011A)
366911-01	SB 216763 (SB216763, SB-216763, SCHEMBL30251)
BA5664-5	SB-649868

SB-612111

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