Terpendole I

• Target:

  Others|||Endogenous Metabolite|||Acyltransferase

• Related Pathways:

  Others|||Metabolism

• Bioactivity:

  Terpendole I is a fungal metabolite that has been found in A. yamanashiensis.1 It is a weak inhibitor of acyl-coenzyme A:cholesterol acyltransferase (ACAT; IC50 = 145 ?M) and is active against the bacteria B. cereus and B. subtilis (MICs = 100 ?g/ml for both) but not S. aureus, P. aeruginosa, or K. pneumoniae (MICs = >200 ?g/ml for all) or the fungus C. albicans (MIC = 200 ?g/ml) .1,2 It is cytotoxic to HeLa cells with an IC50 value of 52.6 ?M.3

• Smiles:

  [H][C@]12Cc3c([nH]c4ccccc34)[C@]1(C)[C@@]1(C)CC[C@]3([H])O[C@@H]([C@@H](O)[C@H]4O[C@@]34[C@]1(O)CC2)C(C)(C)O

• Molecular Formula:

  C27H35NO5

• Molecular Weight:

  453.579

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  167612-17-1