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Terpendole I

CAT: 0931-T36329Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T36329Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
167612-17-1
Target
Others, Endogenous Metabolite, Acyltransferase
Related Pathways
Others, Metabolism
Bioactivity
Terpendole I is a fungal metabolite that has been found in A. yamanashiensis.1 It is a weak inhibitor of acyl-coenzyme A:cholesterol acyltransferase (ACAT; IC50 = 145 μM) and is active against the bacteria B. cereus and B. subtilis (MICs = 100 μg/ml for both) but not S. aureus, P. aeruginosa, or K. pneumoniae (MICs = >200 μg/ml for all) or the fungus C. albicans (MIC = 200 μg/ml) .1,2 It is cytotoxic to HeLa cells with an IC50 value of 52.6 μM.3
Smiles
[H][C@]12Cc3c([nH]c4ccccc34)[C@]1(C)[C@@]1(C)CC[C@]3([H])O[C@@H]([C@@H](O)[C@H]4O[C@@]34[C@]1(O)CC2)C(C)(C)O
Molecular Formula
C27H35NO5
Molecular Weight
453.579
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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