BI-3663

• Target:

  PROTACs|||FAK

• Related Pathways:

  Cytoskeletal Signaling|||PROTAC|||Tyrosine Kinase/Adaptors|||Angiogenesis

• Bioactivity:

  BI-3663 is a highly selective PTK2/FAK PROTAC that utilizes cereblon ligands to hijack E3 ligases for PTK2 degradation, with an IC50 of 18 nM. It is composed of BI-4464 linked to Pomalidomide with a linker[1]. Anti-cancer.

• Smiles:

  O=C(NCCOCCOCCOCCC(=O)NC1=CC=CC=2C(=O)N(C(=O)C12)C3C(=O)NC(=O)CC3)C4=CC=C(NC5=NC=C(C(=N5)OC6=CC=CC7=C6C(=O)CC7)C(F)(F)F)C(OC)=C4

• Molecular Formula:

  C44H42F3N7O12

• Molecular Weight:

  917.84

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2341740-84-7