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BI-3663

CAT: 0931-T17543-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T17543-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2341740-84-7
Target
PROTACs, FAK
Related Pathways
Cytoskeletal Signaling, PROTAC, Tyrosine Kinase/Adaptors, Angiogenesis
Bioactivity
BI-3663 is a highly selective PTK2/FAK PROTAC that utilizes cereblon ligands to hijack E3 ligases for PTK2 degradation, with an IC50 of 18 nM. It is composed of BI-4464 linked to Pomalidomide with a linker[1]. Anti-cancer.
Smiles
O=C(NCCOCCOCCOCCC(=O)NC1=CC=CC=2C(=O)N(C(=O)C12)C3C(=O)NC(=O)CC3)C4=CC=C(NC5=NC=C(C(=N5)OC6=CC=CC7=C6C(=O)CC7)C(F)(F)F)C(OC)=C4
Molecular Formula
C44H42F3N7O12
Molecular Weight
917.84
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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