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CAY10681

CAT: 0931-T36191-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0931-T36191-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1542066-69-2
Target
Others
Related Pathways
Others
Bioactivity
Inactivation of the tumor suppressor p53 commonly coincides with increased signaling through NF-?B in cancer. CAY10681 is a dual modulator of p53-MDM2 interaction and NF-?B signaling. It potently binds MDM2 (Ki = 250 nM), reducing MDM2-mediated turnover of p53. CAY10681 also inhibits phosphorylation of I?B? and dose-dependently reduces nuclear accumulation of p65. It blocks the proliferation of cancer cell lines (IC50s range from 33 to 37 ?M) . CAY10681 exhibits excellent oral bioavailability and inhibits tumor growth in A549 xenografts in nude mice.
Smiles
C(CCN1C=CN=C1)N2C(C3=C(N(CC4=CC=CC=C4)N=C3C5=CC=CC=C5)C2=O)C6=CC=C(Br)C=C6
Molecular Formula
C30H26BrN5O
Molecular Weight
552.46
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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