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Neospiramycin I

CAT: 0931-T36183-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T36183-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
70253-62-2
Target
Others, Antibacterial, Antibiotic
Related Pathways
Others, Microbiology/Virology
Bioactivity
Neospiramycin I is a macrolide antibiotic and derivative of spiramycin I.1It is active against the macrolide-sensitive KB210, but not the macrolide-resistant KB224, strain ofS. aureus (MICs = 3.12 and >100 μg/ml, respectively), as well asB. cereus, B. subtilis, M. luteus, E. coli, andK. pneumoniae (MICs = 1.56, 3.12, 3.12, 0.2, 50, and 12.5 μg/ml, respectively) . Neospiramycin I binds toE. coliribosomes with an IC50value of 1.2 μM. It protects against mortality in a mouse model ofS. pneumoniaetype III infection (ED50= 399.8 mg/kg) .2
Smiles
CO[C@H]1[C@H](O)CC(=O)O[C@H](C)C\C=C\C=C\[C@H](O[C@H]2CC[C@@H]([C@@H](C)O2)N(C)C)[C@H](C)C[C@H](CC=O)[C@@H]1O[C@@H]1O[C@H](C)[C@@H](O)[C@@H]([C@H]1O)N(C)C |t:12,14|
Molecular Formula
C36H62N2O11
Molecular Weight
698.895
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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Alternative Products

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GTR19223049-01Neospiramycin
GTR19192213-01Neospiramycin I
AR-S10759-01Spiramycin Impurity 1 (Neospiramycin)
257384-01NeoSpiramycin I discontinued. See 018076
AR-S10751-01Spiramycin EP Impurity A (Neospiramycin I)
AR-S10761-01Spiramycin EP Impurity H (Neospiramycin III)
AR-S10758-01Spiramycin EP Impurity G (Neospiramycin II)

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