Concanamycin B

• Target :

  Proton pump|||Others|||Antibiotic

• Related Pathways :

  Membrane transporter/Ion channel|||Microbiology/Virology|||Others

• Bioactivity :

  Concanamycin B is a macrolide antibiotic that selectively inhibits vacuolar type H+-ATPases (IC50 = 5 nM), thereby blocking vacuolar organelle acidification and early to late endosomal transport. It interferes with bone resorption, maturation of CD8 T lymphocytes, and prevents processing of major histocompatibility complex (MHC) class II precursors in human B cells, inhibiting MHC class II molecule expression on the cell surface.

• Smiles :

  [H][C@@]1(C[C@@H](O)[C@H](OC(N)=O)[C@@H](C)O1)O[C@@H]1C[C@@](O)(O[C@H](\C=C\C)[C@H]1C)[C@@H](C)[C@H](O)[C@H](C)[C@@]1([H])OC(=O)\C(OC)=C\C(\C)=C\[C@@H](C)[C@H](O)[C@@H](C)[C@H](O)[C@H](C)C\C(C)=C\C=C\[C@@H]1OC

• Molecular Formula :

  C45H73NO14

• Molecular Weight :

  852.072

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  81552-33-2