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Concanamycin B

CAT: 0931-T36116Size: 1 mgDry Ice: NoHazardous: No
CAT#:0931-T36116Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
81552-33-2
Target
Proton pump|||Others|||Antibiotic
Related Pathways
Membrane transporter/Ion channel|||Microbiology/Virology|||Others
Bioactivity
Concanamycin B is a macrolide antibiotic that selectively inhibits vacuolar type H+-ATPases (IC50 = 5 nM), thereby blocking vacuolar organelle acidification and early to late endosomal transport. It interferes with bone resorption, maturation of CD8 T lymphocytes, and prevents processing of major histocompatibility complex (MHC) class II precursors in human B cells, inhibiting MHC class II molecule expression on the cell surface.
Smiles
[H][C@@]1(C[C@@H](O)[C@H](OC(N)=O)[C@@H](C)O1)O[C@@H]1C[C@@](O)(O[C@H](\C=C\C)[C@H]1C)[C@@H](C)[C@H](O)[C@H](C)[C@@]1([H])OC(=O)\C(OC)=C\C(\C)=C\[C@@H](C)[C@H](O)[C@@H](C)[C@H](O)[C@H](C)C\C(C)=C\C=C\[C@@H]1OC
Molecular Formula
C45H73NO14
Molecular Weight
852.072
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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