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Dichlorphenamide-13C6

CAT: 0931-T36059Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0931-T36059Size:2 mg
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CAS Number
1391054-76-4
Target
Carbonic Anhydrase
Related Pathways
Metabolism
Bioactivity
Dichlorphenamide-13C6is intended for use as an internal standard for the quantification of dichlorphenamide by GC- or LC-MS. Dichlorphenamide is a sulfonamide and an orally bioavailable carbonic anhydrase (CA) inhibitor (Kis = 1.20, 38, 50, and 50 nM for the human CA isoforms CAI, CAII, CAIX, and CAXII, respectively) .1It lowers intraocular pressure in rabbits when 50 μl of a 10% solution is applied topically to the eye.2Dichlorphenamide rescues the potassium deficiency and prevents insulin-induced paralysis in a rat model of familial hypokalemic periodic paralysis when administered at a dose of 5.6 mg/kg per day for ten days.3Formulations containing dichlorphenamide have been used in the treatment of glaucoma and primary periodic paralysis.
Smiles
NS(=O)(=O)[13c]1[13cH][13c](Cl)[13c](Cl)[13c]([13cH]1)S(N)(=O)=O
Molecular Formula
C6H6Cl2N2O4S2
Molecular Weight
311.1
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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