Nebentan

• Target:

  Others|||Endothelin Receptor

• Related Pathways:

  GPCR/G Protein|||Others

• Bioactivity:

  Nebentan (YM598) is a potent, selective and orally active non-peptide endothelin ETA receptor antagonist through the modification of Bosentan . Nebentan inhibits [125I] endothelin-1 binding to cloned human endothelin ETA and ETB receptor, with Ki of 0.697 nM and 569 nM, respectively[1]. YM598 can ameliorate the progression of cor pulmonale and myocardial infarction in vivo[2].

• Smiles:

  COc1ccccc1Oc1c(NS(=O)(=O)\C=C\c2ccccc2)nc(nc1OC)-c1ncccn1

• Molecular Formula:

  C24H21N5O5S

• Molecular Weight:

  491.52

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  403604-85-3