T-5342126

• Target:

  Others|||TLR

• Related Pathways:

  Immunology/Inflammation|||Others

• Bioactivity:

  T-5342126 is a toll-like receptor 4 (TLR4) antagonist that reduces LPS-induced production of nitric oxide (NO) in RAW 264.7 cells (IC50 = 27.8 ?M) and decreases LPS-induced IL-8, TNF-?, and IL-6 production in isolated human whole blood (IC50s = 110.5, 315.6, and 318.4 ?M, respectively) . T-5342126 (82 mg/kg) also reduces ethanol intake and the abundance of ionized calcium-binding adapter molecule 1 (Iba1), a marker of microglial activation, in the central nucleus of the amygdala in ethanol-dependent mice.

• Smiles:

  C(N1C(C)=C(CN(CC(COC2=CC=C(OCC)C=C2)O)C)C(C)=N1)C3=C(Cl)C=CC=C3

• Molecular Formula:

  C25H32ClN3O3

• Molecular Weight:

  457.99

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  956507-49-6