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Nodularin

CAT: 0931-T35777Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0931-T35777Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
118399-22-7
Target
Others, Phosphatase
Related Pathways
Metabolism, Others
Bioactivity
The cyanobacterium Nodularia spumigena often contaminates the drinking water of rural communities in developing countries and accumulates in mussels, flounder, and cod from the northern Baltic Sea. Nodularin is a hepatotoxic monocylic pentapeptide produced by the N. spumigena. It is a potent inhibitor of protein phosphatase types 1 (PP1) and 2A (PP2A), exhibiting IC50 values of 1.8 and 0.026 nM, respectively. PP2B is inhibited to a lesser extent with an IC50 of 1.8 μM. No apparent inhibitory effect is observed with PP2C, alkaline phosphatase, acid phosphatase, insulin receptor tyrosine kinase, protein kinase A, phosphorylase kinase, or protein kinase C.
Smiles
CO[C@@H](Cc1ccccc1)[C@@H](C)\C=C(/C)\C=C\[C@@H]1NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](C)[C@@H](NC(=O)\C(=C\C)N(C)C(=O)CC[C@@H](NC(=O)[C@H]1C)C(O)=O)C(O)=O
Molecular Formula
C41H60N8O10
Molecular Weight
824.977
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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