Butyrolactone V

• Target:

  Others|||Parasite

• Related Pathways:

  Microbiology/Virology|||Others

• Bioactivity:

  Butyrolactone V is a fungal metabolite that has been found in A. terreus and has antiprotozoal, antioxidant, and anticancer activities.1,2,3 It is active against the P. falciparum strain K1 (IC50 = 7.9 ?g/ml) and L. amazonensis promastigotes (IC50 = 23.7 ?M) .2,1 Butyrolactone V (227 and 454.1 ?M) is also active against adult S. mansoni worms.1 It scavenges 2,2-diphenyl-1-picrylhydrazyl and ABTS radicals with IC50 values of 20.7 and 3.7 ?M, respectively, in cell-free assays.3 Butyrolactone V also inhibits proliferation of MDA-MB-231 and MCF-7 breast cancer cells (IC50s = 22.2 and 31.9 ?M, respectively) .1

• Smiles:

  COC (=O) [C@]1 (Cc2ccc3OC (C) (C) [C@@H] (O) Cc3c2) OC (=O) C (O) =C1c1ccc (O) cc1

• Molecular Formula:

  C24H24O8

• Molecular Weight:

  440.44

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1151509-01-1