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Nemadipine-A

CAT: 0931-T35729-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T35729-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
54280-71-6
Target
Calcium Channel, Others
Related Pathways
Metabolism, Others, Membrane transporter/Ion channel
Bioactivity
Nemadipine A is an L-type calcium channel blocker that induces morphological and growth defects in wild-type C. elegans and those with hypoexpression of egl-19, which encodes the only L-type calcium channel α1-subunit in the C. elegans genome. It also inhibits L-type calcium channels in chick ciliary neurons. Nemadipine A increases TRAIL-induced cytotoxicity and synergistically enhances caspase-8 and caspase-3 activation in a concentration-dependent manner in H1299 lung adenocarcinoma cells. It also decreases Survivin expression when used alone or in combination with TRAIL in A549 cells.
Smiles
CCOC(=O)C1=C(C)NC(C)=C(C1C1=C(F)C(F)=C(F)C(F)=C1F)C(=O)OCC
Molecular Formula
C19H18F5NO4
Molecular Weight
419.34
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
HY-126583Nemadipine-A
112139Nemadipine A
TRC-N389800-100MGNemadipine B
sc-203157Nemadipine-B
sc-478016Nemadipine B-d10

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