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Nemadipine-A

CAT: 0804-HY-126583Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-126583Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Nemadipine-A is a specific inhibitor of the EGL-19 L-type Ca2+ channel[1]. Nemadipine-A, a cell-permeable L-type calcium channel inhibitor, sensitizes TRAIL-resistant cancer cells to this ligand[2].
CAS Number
54280-71-6
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Calcium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nemadipine-a.html
Purity
98.0
Solubility
DMSO : 20 mg/mL (ultrasonic; warming)
Smiles
CC1=C(C(C(C(OCC)=O)=C(N1)C)C2=C(C(F)=C(C(F)=C2F)F)F)C(OCC)=O
Molecular Formula
C19H18F5NO4
Molecular Weight
419.34
Precautions
H315, H319, H335
References & Citations
[1]Peter I Joyce, et al. The atypical calpains: evolutionary analyses and roles in Caenorhabditis elegans cellular. PLoS Genet. 2012;8 (3) :e1002602.degeneration|[2]Seong Ho Park, et al. Down-Regulation of Survivin by Nemadipine-A Sensitizes Cancer Cells to TRAIL-Induced Apoptosis. Biomol Ther (Seoul) . 2013 Jan;21 (1) :29-34.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
L-type calcium channel

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MBS5802458Nemadipine-A
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