SHP099

• Target:

  PERK|||Phosphatase

• Related Pathways:

  Apoptosis|||Metabolism

• Purity:

  0.994

• Bioactivity:

  SHP099 (SHP099 free base) free base is an effective, selective, orally bioavailable, and efficacious SHP2 inhibitor (IC50 =0.07 ?M and p-ERK modulation in cells IC50 = 0.250 ?M) . SHP099 shows dose-dependent pathway inhibition and antitumor activity in xenograft models.

• Smiles:

  CC1 (N) CCN (CC1) c1cnc (c (N) n1) -c1cccc (Cl) c1Cl

• Molecular Formula:

  C16H19Cl2N5

• Molecular Weight:

  352.26

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1801747-42-1