SHP099

• Target :

  PERK|||Phosphatase

• Related Pathways :

  Apoptosis|||Metabolism

• Purity :

  0.994

• Bioactivity :

  SHP099 (SHP099 free base) free base is an effective, selective, orally bioavailable, and efficacious SHP2 inhibitor (IC50 =0.07 ?M and p-ERK modulation in cells IC50 = 0.250 ?M) . SHP099 shows dose-dependent pathway inhibition and antitumor activity in xenograft models.

• Smiles :

  CC1(N)CCN(CC1)c1cnc(c(N)n1)-c1cccc(Cl)c1Cl

• Molecular Formula :

  C16H19Cl2N5

• Molecular Weight :

  352.26

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  1801747-42-1